Identification of an on-pathway intermediate illuminates the kinetic competition between protein folding and misfolding

Proceedings of the National Academy of Sciences, Volume 122, Issue 31, August 2025. <br/>SignificanceProtein folding occurs in a kinetic competition with misfolding. Although protein misfolding is the basis for many devastating human diseases, we know little about this competition. Here, we identify an on-pathway folding intermediate for …