Identification of CD164 as an essential entry receptor for divergent adeno-associated viruses

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Proceedings of the National Academy of Sciences, Volume 123, Number 10, March 2026.
SignificancerAAVs are widely used vectors for human gene therapy, but the mechanisms governing their entry into host cells remain incompletely understood. While several AAV serotypes depend on the widely expressed AAV receptor (AAVR) for cellular entry,…

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