Identifying genome-by-childhood trauma interactions for depression using a forest-based approach in the UK Biobank and Adolescent Brain Cognitive Development Study

Proceedings of the National Academy of Sciences, Volume 123, Issue 6, February 2026. <br/>SignificanceDepression is a major public health challenge, yet its genetic basis has been difficult to clarify because risk also depends strongly on environmental exposures such as traumatic experiences. Past attempts to pinpoint single gene-by-…