Single-cell sequencing uncovers sensory neuron–mediated CGRP signaling as a driver of sarcoma progression

Proceedings of the National Academy of Sciences, Volume 122, Number 43, October 2025.
ImportanceBone tumors such as osteosarcoma (OS) cause intense pain, often caused by the skeletal nerve fibers growing into the tumor. In this study, we show that targeting neurons in the tumor microenvironment using chemo-genetic tools reduces OS…