Mutant p53 regulates cancer cell invasion in complex three-dimensional environments through mevalonate pathway–dependent Rho/ROCK signaling

Proceedings of the National Academy of Sciences, Volume 122, Number 43, October 2025.
Significance This study addresses the contribution of mutant p53 to the process of cancer cell dissemination in physiologically relevant three-dimensional environments, a key feature of metastatic disease. Several mutant p53 proteins exhibit pro-…