Improving the efficacy of anti-SSEA4 antibody in pancreatic cancer immunotherapy with glyco-optimization and immune checkpoint blockade

Proceedings of the National Academy of Sciences, Volume 122, number 38, September 2025.
The cancer of the service of the period was very fatal with limited treatment options emphasizing the need for alternative therapeutic approaches. We have shown that SSEA4 is a promising therapeutic target and anti-SESA4 antibodies glycoincinered …