A CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation

Proceedings of the National Academy of Sciences, Volume 123, Number 12, March 2026.
Importance Cancer cells are often faced with chronic glutamine deficiency in poorly perfused tumors, but the mechanisms allowing their survival remain poorly understood. Here we identify an alpha choline kinase (CHKA) – promyelocytic leukemia (PML) – WD…