Inhibition of FicD-mediated AMPylation and deAMPylation by isoprenoid diphosphates
https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c
Proceedings of the National Academy of Sciences, Volume 123, Number 10, March 2026.
SignificanceFicD regulates unfolded protein response (UPR) signaling in metazoans by adjusting the capacity of BiP chaperones. Therefore, targeting FicD activity may be a practical method to modify UPR signaling for therapeutic benefit. We identify geranyl-…
