Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice

Proceedings of the National Academy of Sciences, Volume 122, Issue 27, July 2025. <br/>SignificanceThis research explores how astrocytes, specialized brain cells, regulate cerebral blood flow (CBF). Astrocytes elevate calcium (Ca2+) and/or cyclic adenosine monophosphate (cAMP) after sensing neuronal activity. Astrocytic Ca2+increases have …