Bivalent interaction through an intrinsically disordered linker promotes transcription activation complex assembly in Notch signaling

Proceedings of the National Academy of Sciences, Volume 122, Issue 30, July 2025. <br/>SignificanceCells change their identity through the Notch signaling pathway, which alters gene expression. Notch alters gene expression by forming a heterotrimer composed of three proteins: CSL, RAMANK, and MAML. The CSL-RAMANK-MAML heterotrimer has an …