L-lactic acid enhances type I interferon immune response and inhibits virus infection by promoting IRF9 L-lactylation

Proceedings of the National Academy of Sciences, Volume 123, Number 1, January 2026.
ImportanceLactic acid was often considered a well-known metabolic waste product. However, recent studies have shown that lactic acid can be an important circulating carbohydrate fuel. Here, we observed a dual role of L-lactic acid in viral infection: …