Lakers vs. Grizzlies prediction, odds: Friday NBA picks from proven model

The Los Angeles Lakers take on the Memphis Grizzlies on Friday night in a 2025 NBA Cup game. Los Angeles will once again be without small forward LeBron James (nerve issue), although Luka Doncic (knee/finger) has become questionable. Memphis will be without point guard Scotty Pippen Jr. (toe) and center Zach Edey (ankle). The Lakers (3-2), coming off a 116-115 victory at Minnesota on Wednesday, are 2-0 on the road this season. The Grizzlies (3-2), who beat Phoenix 114-113 on Wednesday, are 2-1 on their home court.

News from the FedEx Forum in Memphis is scheduled for 9:30 p.m. ET. The Lakers lead the all-time series 69-41, with wins in each of the last three meetings. Memphis is a 1.5-point favorite in the latest Lakers vs. Grizzlies odds from SportsLine consensus, while the over/under in total points scored is 237.5. Before making any Grizzlies vs. Lakers picks, check out the NBA predictions and betting tips from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profits for $100 players on its top-rated NBA picks over the past seven seasons. The model enters Week 2 of the 2025-26 NBA season with a scorching 161-120 score on all top-rated NBA picks, netting nearly $4,000. He also went 24-11 (69%) on the NBA’s top-rated picks against the spread last season. Anyone who follows his NBA betting tips on sports betting sites and betting apps could have seen huge returns.

Today, the model has simulated Lakers vs. Grizzlies 10,000 times and just revealed its coveted NBA picks and betting predictions. You can now head over to SportsLine to see the model’s choices. Here are several NBA odds and NBA betting lines for the Lakers vs. Grizzlies:

Why the Grizzlies can cover

Guard Ja Morant helps lead Memphis’ offense. In five starts this season, he averages 23.4 points, 6.6 assists, 3.8 rebounds and one steal in 28 minutes. In the win over the Suns, he scored 28 points, while adding eight rebounds, seven assists and two steals. In a 128–122 victory over the New Orleans Pelicans on October 22, he scored 35 points, while adding three rebounds and three assists.

Forward Jaren Jackson Jr. is one of five Memphis players averaging double figures. In five starts, he is averaging 17.6 points, 5.2 rebounds, 1.6 blocks, 1.2 assists and one steal in 26.8 minutes. Against Phoenix, he scored 18 points, while adding six rebounds, three steals and three assists. He had 19 points and three rebounds in a 146-114 loss to the Miami Heat on October 24. Find out which team to support on SportsLine.

Why the Lakers can cover

Guard Austin Reaves is on a roll to start the season. In five starts, he is averaging 34.2 points, 10 assists, 5.6 rebounds and 1.8 steals in 38.2 minutes. In a 127-120 win at Sacramento on Sunday, he scored 51 points, while grabbing 11 rebounds and dishing out nine assists. He had 41 points, five assists, four rebounds and three steals in a 122-108 loss to the Portland Trail Blazers on Monday.

Striker Rui Hachimura is having a good start to the season. He is one of five players in Los Angeles averaging double figures. In five starts, he is averaging 16.6 points, four rebounds and two assists in 36.2 minutes. In a 128–110 victory over the Minnesota Timberwolves on October 24, he scored 23 points, while grabbing two rebounds in 32 minutes. Find out which team to support on SportsLine.

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How to make Lakers vs. Grizzlies picks

SportsLine’s model has simulated Lakers vs. Grizzlies 10,000 times and backs the total, projecting 238 combined points. The model also indicates that one side of the spread represents the best value. You can head to SportsLine to see the model’s NBA picks.

So who wins the Lakers over the Grizzlies, and which side of the spread offers the best value? Visit SportsLine now to see which way the Lakers vs. Grizzlies spread, all from the model that brought in well over $10,000 on top-rated NBA picks, and find out.