Leaderless RiPPs expand the repertoire of fungal secondary metabolites

Proceedings of the National Academy of Sciences, Volume 123, Number 7, February 2026.
SignificanceThe identification of a novel subclass of ribosome-synthesized post-translationally modified peptides (RiPPs) in fungi, a subclass lacking a leader sequence, challenges the traditional understanding of fungal RiPPs. By linking MSDIN genes to…