Tumor-expressed GPNMB orchestrates Siglec-9+ TAM polarization and EMT to promote metastasis in triple-negative breast cancer

Proceedings of the National Academy of Sciences, Volume 122, Issue 36, September 2025. <br/>SignificanceMetastasis is the primary cause of cancer-related deaths, yet the glyco-immunological mechanisms by which the tumor microenvironment (TME) regulates this process remain incompletely understood. Glycoprotein nonmetastatic melanoma protein B (…