Lipid nanoparticle–mediated in vivo generation of panCAR immune cells for solid tumor immunotherapy

Proceedings of the National Academy of Sciences, Volume 123, Issue 8, February 2026. <br/>SignificanceThe complexity and immunosuppressive nature of tumor microenvironment (TME) significantly hindered the efficacy of current immunotherapies, emphasizing the need for therapeutic strategies with polypharmacology and multifunctionality to …