Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson’s disease

Proceedings of the National Academy of Sciences, Volume 122, Issue 31, August 2025. <br/>SignificanceA hallmark of Parkinson’s disease is loss of dopamine neurons that project to a brain region called the dorsal striatum. We showed previously that LRRK2 mutations block cilia formation in rare striatal cells that provide neuroprotective …