M cell–dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer’s patches

Proceedings of the National Academy of Sciences, Volume 123, Number 2, January 2026.
ImportanceMultiple sclerosis (MS) is a chronic autoimmune disease influenced by complex interactions between genetic and intestinal microbiota. We identify Peyer’s patch (PP) M cells as an essential gateway for the uptake of commensal bacteria, inducing…