Mapping cell fate transition in space and time

Nature Biotechnology, Published online: 16 July 2025; doi:10.1038/s41587-025-02704-x

Cells in a tissue influence each other through physical and chemical cues as they differentiate to their final fates and migrate through space. A new technique integrates spatial transcriptomic data with the dynamics of RNA transcription and splicing across an entire tissue to model the directions of cell differentiation and migration.