USP1–TRAF2 axis–regulated mortalin stability mediates chemoresistance by disrupting calcium transport in peripheral T-cell lymphoma
https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c
Proceedings of the National Academy of Sciences, Volume 122, Number 48, December 2025.
ImportancePeripheral T-cell lymphoma (PTCL) remains a therapeutic challenge due to poorly understood chemoresistance mechanisms. Here, we identify ubiquitin-specific peptidase 1 as a clinically druggable target driving chemoresistance by promoting…
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