Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition | Science

The CRL4CRBN E3 Ubiquitin Ligase is the target of the compounds of degrading of molecular glue which reprogramly the specificity of the ligase to induce the degradation of clinically relevant neosubstate proteins. The known cereblon (CRBN) neosubstates share a generalizable β -..