Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway

Proceedings of the National Academy of Sciences, Volume 122, Issue 40, October 2025. <br/>SignificanceHow cells convert potentially damaging mitochondrial and oxidative stress into protective stress-induced mitophagy responses remains unclear. Here, we identified mtROS as a potent signaling molecule that drives PINK1/Parkin-dependent mitophagy …