MLKL/retromer axis controls PD-L1 recycling to compromise antitumor immunity during VCP inhibition–induced necroptosis

Proceedings of the National Academy of Sciences, Volume 122, Issue 51, December 2025. <br/>SignificanceTumor cells exploit programmed death ligand 1 (PD-L1) for immune evasion. The dynamic trafficking of PD-L1 within intracellular compartments can be regulated by cell stress or death signals, which impacts the therapeutic benefits. However, the …