MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic cancer

Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br/>SignificanceThis report investigates mechanisms underlying the dependence of MYC-amplified pancreatic cancer cells on the MYC network member MondoA which, as a heterodimer with MLX, is a nutrient-sensing transcription factor. We show this dependency is …