mtDNA leakage promotes neuron–glia crosstalk to induce epilepsy by cGAS–STING-driven neuroinflammation and serine metabolic reprogramming

Proceedings of the National Academy of Sciences, Volume 123, Number 9, March 2026.
SignificanceEpilepsy is traditionally considered a disorder of excessive neuronal firing, but increasing evidence implicates metabolic dysregulation. Here, we identify a mitochondria-immunity-metabolism axis linking neuronal mitochondrial damage to chronic damage…