Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding

Proceedings of the National Academy of Sciences, Volume 122, Issue 48, December 2025. <br/>SignificanceWe identified the molecular class of pteridines as natural ligands of the cryptic CutA protein, including a so far unknown 2’-deoxyxanthopterin B2. Our data showed increased copper binding to CutA in the presence of pteridines. Together, these …