The α-synuclein proteostasis network and its translational applications in Parkinson’s disease

Proceedings of the National Academy of Sciences, Volume 123, Number 12, March 2026.
Significance Since the breakdown of proteostasis underlies many neurodegenerative disorders, it is important to develop quantitative frameworks for its assessment. Here, we map the α-synuclein (α-Syn) proteostasis network in human substantia nigra integrating…