Neural crest cell recruitment and reprogramming as central drivers of embryonic limb regeneration

Proceedings of the National Academy of Sciences, Volume 122, Issue 52, December 2025. <br/>SignificanceMouse embryos possess the remarkable ability to regenerate amputated forelimb buds at E10.5—a capacity lost just 2 d later. We identify neural crest cells (NCCs) as key drivers in this transient regeneration. After limb amputation, NCCs …