Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans

Proceedings of the National Academy of Sciences, Volume 123, Number 1, January 2026.
SignificanceGlioblastoma, the most fatal primary brain tumor in adults, exerts physical forces on surrounding brain tissue, resulting in neuronal damage. In the present study, by applying several model systems, we show that chronic mechanical compression…