LHFPL5 is required for maximal activation of the mechanotransduction channel in cochlear hair cells

Proceedings of the National Academy of Sciences, Volume 122, Issue 45, November 2025. <br/>SignificanceThe mechanotransduction complex of cochlear hair cells is an astonishing molecular machine consisting of the ion channel subunits TMC1/2, TMIE, and CIB2, the tetraspan LHFPL5, and the tip link proteins PCDH15 and CDH23. Tip links are thought …