Nir2 crystal structures reveal a phosphatidic acid–sensing mechanism at ER–PM contact sites
https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c
Proceedings of the National Academy of Sciences, Volume 122, Number 43, October 2025.
ImportancePhosphatidic acid (PA) is a lipid intermediate produced during phospholipase C (PLC) signaling, and its levels must be precisely regulated to maintain appropriate signaling and lipid homeostasis at the membrane. Nir2 is a crucial lipid transfer…
