NPC1 trafficking via VPS41-dependent LAMP carriers regulates endosomal cholesterol homeostasis

Proceedings of the National Academy of Sciences, Volume 122, Issue 52, December 2025. <br/>SignificanceNiemann–Pick protein 1 (NPC1) is a lysosomal cholesterol transporter that is critical for cholesterol egress from lysosomes. Mutations in theNPC1gene results in lysosomal cholesterol accumulation and development of the lysosomal storage …