OGG1 augments the transcriptional activation of Foxp3 to promote iTreg differentiation for IBD alleviation

Proceedings of the National Academy of Sciences, Volume 122, Issue 30, July 2025. <br/>SignificanceDNA glycosylase OGG1 is increasingly recognized for the roles beyond genome maintenance. Here, we identify a function for OGG1 in regulating immune tolerance by promoting the differentiation of inducible regulatory T cells (iTregs). OGG1 …