eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

Proceedings of the National Academy of Sciences, Volume 122, Issue 30, July 2025. <br/>SignificanceThis work identifies eIF4A as a major regulator of both estrogen receptor (ER) translation and breast cancer growth. We demonstrate that eIF4A is required to maintain ER expression and expression of cell cycle regulators such as cyclin D1 and …