p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer

Proceedings of the National Academy of Sciences, Volume 122, Number 44, November 2025.
Significance We report that p53 cooperates with the estrogen receptor to transcriptionally regulate chromatin modifiers in breast cancer, orchestrating an epigenetic landscape that restricts stem cell characteristics, maintains expression of luminal cell identity…