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The mechanism of pathogenic α1-antitrypsin aggregation in the human liver

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Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceThe self-assembly of members of the serpin superfamily into chains of molecules (“polymers”) contributes to the progression of their associated conformational pathologies. Here, the subunit architecture of polymers that form in human tissue …

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