How RAG1/2 evolved from ancestral transposases to initiate V(D)J recombination without transposition

Proceedings of the National Academy of Sciences, Volume 122, number 31, August 2025.
The significant study has determined two key structures of the gene signal complex activating the genes (RAG), SEC-0 and Homeodoman SECLANT (PHD). Sec -0 adopts a closed state of product, supporting a “spring” mechanism, by which a open to -…