Photoenzymatic Csp3–Csp3 bond formation via enzyme-templated radical–radical coupling

Proceedings of the National Academy of Sciences, Volume 123, Issue 7, February 2026. <br/>SignificanceCross-coupling reactions are foundational to modern synthesis, yet forming C(sp3)–C(sp3) bonds remains one of the most difficult challenges in catalysis. Here, we show that enzymes can facilitate this reactivity via radical–radical coupling …