Stress granule–mediated ZBP1 activation drives necroptotic cell death in non-obstructive azoospermia and testicular aging

Proceedings of the National Academy of Sciences, Volume 122, number 33, August 2025.
Significantly the causes of male infertility and reproductive aging remain largely elusive. This study identifies a necroptotic route, initiated by the formation of stress granules and mediated by ZBP1 and RIPK3, as a key mechanism resulting in the loss of testicular …