Single-cell multiomic and spatial landscape of the primate pineal gland reveals circadian and melatonin regulatory architecture

Proceedings of the National Academy of Sciences, Volume 123, Number 19, May 2026.
Significance The pineal gland is a central regulator of circadian rhythms and neuroendocrine homeostasis in primates, but its cellular diversity and spatial regulatory logic remain poorly defined. By integrating mononuclear and spatial multiomics into…