Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization

Proceedings of the National Academy of Sciences, Volume 123, Number 3, January 2026.
Significance The ubiquitin-proteasome system (UPS) controls the turnover of oncogenes and tumor suppressors, but how its activity is regulated within distinct subcellular compartments and how this affects cancer progression remains unclear. We show that p62/…