Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial function

Proceedings of the National Academy of Sciences, Volume 122, Number 47, November 2025.
SignificanceAcute kidney injury caused by loss of blood flow to the proximal tubule is a major cause of morbidity and mortality. Indeed, this type of cell rich in mitochondria is very sensitive to ischemia. Here, we find that Rac1, a regulator of…