RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ

Proceedings of the National Academy of Sciences, Volume 122, number 24, June 2025.
The development and function of the significant macrophages of the macrophage (AM) depends on the transcription factor signature of the receiver-γ (pparγ) activated by the proliferators. The regulation of the stability of PPARγ during the development and maintenance of the AM remains unexplored. Here, …