Capped high-force integrin bond lifetimes and spacing-tuned binding frequency drive rapid fibroblast migration

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. <br/>SignificanceThe turnover and strength of integrin-mediated adhesions are central to regulate the cell–microenvironment interaction, especially during cell migration. However, the mechanism of how integrin binding dynamics modulate the migratory behavior …