Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements

Proceedings of the National Academy of Sciences, Volume 122, Issue 43, October 2025. <br/>SignificanceTransposable elements (TEs) constitute about half of the vertebrate genome. Previously, we provided evidence that TE silencing by CpG methylation in the germ line and subsequent deamination resulted in strong CpG depletion not only in the TEs …