RyR1-mediated Ca2+-induced Ca2+ release plays a negligible role in excitation–contraction coupling of normal skeletal muscle
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Proceedings of the National Academy of Sciences, Volume 122, number 34, August 2025.
Receiver of significant ryanodin 1 Ryanodine (Ryr1) is a CA2 + liberation channel in the sarcoplasmic reticulum in the skeletal and critical muscle for the retraction-contract (EC) retraction. Ryr1 opens with two modes: Liberation of CA2 + induced by depolarization (DICR) and CA2 + -…
