S-adenosylmethionine metabolism buffering is regulated by a decrease in glycine N-methyltransferase via the nuclear ubiquitin–proteasome system

Proceedings of the National Academy of Sciences, Volume 122, Issue 26, July 2025. <br/>SignificanceS-adenosylmethionine (SAM) metabolism is crucial for diverse functions, mediated through methylation. Although the feedback regulation of SAM production has been explored extensively, our understanding of the mechanism behind SAM consumption …