SARS-CoV-2 S assembly into virions facilitated by host ERM proteins

Proceedings of the National Academy of Sciences, Volume 123, Number 5, February 2026.
Significance This study reveals a critical host-pathogen interaction leading to the incorporation of the SARS-CoV-2 Spike (S) protein into virions via its binding to cytoskeletal ERM proteins, a conserved mechanism among highly pathogenic coronaviruses. By …