Scalable and accurate rare-variant association tests for whole genome sequencing time-to-event analysis in large biobanks

Proceedings of the National Academy of Sciences, Volume 123, Number 9, March 2026.
SignificanceRare variants (RVs) identified by whole genome sequencing hold great promise for elucidating the genetic basis of disease onset, but existing methods of RV association testing are not well suited to time-to-onset phenotypes. Here we…