CHAMP1 complex promotes heterochromatin assembly and reduces replication stress

Proceedings of the National Academy of Sciences, Volume 123, Number 1, January 2026.
SignificanceReplication stress (RS) is a major driver of genome instability in cancer. We discovered that the CHAMP1 complex, a set of proteins that assemble heterochromatin, plays a critical role in alleviating RS. By depositing repressive histone marks,…