SEL1L–HRD1 ERAD–autophagy interplay maintains mitochondrial homeostasis in brown adipocytes

Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificanceAdaptive thermogenesis in brown adipose tissue demands exceptional control of organelle quality and proteostasis. How mitochondria maintain integrity under high metabolic demand remains unclear. Here, we identify coordinated action between the …